Our Founding Story

About Our Founder
Annee de Mamiel is an internationally acclaimed integrative facialist and the creator of de Mamiel skincare. With a global waiting list and clients ranging from red carpet celebrities to top athletes, her treatments extend well beyond conventional facials, addressing not only the skin but also the entire body, including the nervous system and emotional wellbeing.
Her whole-body approach draws on her extensive training in Anatomy and Physiology, Chinese Medicine, Acupuncture, Clinical Aromatherapy, Craniosacral Therapy, and Breathwork. Combining her deep clinical expertise with an intuitive grasp of the skin, her facials and product formulations work on multiple levels, targeting the skin, nervous system, fascia, lymphatic system, and emotional health.
At the core of de Mamiel is the conviction that supporting the skin, mind, and body together enables authentic and lasting transformation.
The result is what we call the de Mamiel difference: visibly balanced, radiant skin, supported at a deeper level so the effects last far beyond the treatment room
Born in the clinic, built on real skin
After years of hands-on clinical work treating clients in London, New York and Los Angeles, Annee created de Mamiel skincare, shaped by her work with real skin and real lives. Across all her global clients, she was consistently seeing the same issues showing up, from dullness, sensitivity and redness to imbalanced, reactive and tired looking skin, All of which, Annee realised were the result of how modern life imprints itself on the skin.
Stress, pace of life and pressure don’t simply show up on the surface; they influence how skin functions, repairs and ages over time. While external skin aggressors including UV, pollution are well documented, what became clear was that the internal issues such as stress, lack of sleep, emotions and nervous system misalignment can all have an equally detrimental effect on skin health.
Every de Mamiel product is formulated to work on your skin and deep within it, and with its unique clinical aromatherapy blends that also treat the nervous system and emotions to deliver radiant, resilient and truly healthy complexion for now and for the future.
Made with intention, built to work
Most skincare focuses on surface correction. de Mamiel delivers so much more, working on and within your skin, whilst supporting your nervous system and how your skin respond to stress. The result: truly radiant skin health. Each product is formulated in England by Annee, shaped by decades of working with real skin, combining advanced science with intuitive precision to deliver results you can feel immediately and a glow as good as it feels.
This is Modern skincare, led by neuroscience
There has always been a quiet belief at the heart of de Mamiel
There has to be more:
More than surface correction.
More than short-term solutions.
More than skincare that ignores the emotional and biological reality of how we live.
Featured collection
Type:
First Fix - Healthy Skin Hero
RESTORE + PROTECT
Type:
Restorative Cleansing Balm
CLEANSE + RESTORE
Type:
Overnight Exfoliating Oil
POLISH + BRIGHTEN
Science Meets Soul
Where Science Meets Soul
At de Mamiel, the meeting of science and soul is not just a philosophy, it is a practice.
We work from the understanding that emotional wellbeing and physiology are inseparable, and that lasting skin health is shaped by both.
The Science
Our science is quiet and exacting delivering real and lasting results for transforming skin
Advanced, multi-layered actives
High-performance biotech actives that work across hydration, barrier, microbiome and cellular resilience —layered for cumulative effect. Our formulas are designed to deliver results you can see immediately, while building strength and resilience over time.
Neuroscience-led skin signalling
Skin function is influenced by the nervous system, stress mediators, and circadian rhythm. Our formulas work with these signals — not just structural repair.
Rhythm-aware formulation
Products are designed to support skin at different moments of the day and night, respecting repair cycles and stress
recovery.
Sensory delivery as function
Aromatherapy and ritual are not aesthetic — they are delivery systems that influence stress pathways and skin behaviour.








